This allows a branch migration process to occur where the strands move through the junction point.
2.
RuvA and RuvB are branch migration proteins, while RuvC is a junction-resolving enzyme.
3.
An updated model by Matt Meselson and Charley Radding in 1975 introduced the idea of branch migration.
4.
He was also the first to show that RuvA and RuvB are motor proteins that mediate Holliday junction branch migration.
5.
The resulting single Holliday junction then slides down the DNA duplex in the same direction in a process called branch migration, displacing the extended strand from the template strand.
6.
Also, the concept of branch migration isn't discussed until a couple of paragraphs from now, so I think this sentence could be confusing to the average reader.
7.
The other articles that were considered were, Branch Migration, Acetyltransferase, Paraptosis, Ubiquitin-conjugating enzyme, Bacteriolytic and Equine arteritis virus leader TRS hairpin ( LTH ).
8.
This model provided convenient explanation for the strict requirement for homology between recombining sites, since branch migration would stall at a mismatch and would not allow the second strand exchange to occur.
9.
The final step in branch migration is called resolution and requires the protein RuvC . The protein is a dimer, and will bind to the Holliday junction when it takes on the stacked X form.
10.
In this reaction, the incoming strand binds to a single-stranded toehold region of a double-stranded complex, and then displaces one of the strands bound in the original complex through a branch migration process.
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